E-ISSN 3041-4172
 
2024, Vol: 1, Issue: 1
1 / 1Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article

Online Publishing Date:
15 / 03 / 2024



A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles

Laksmi Hartajanie, Siti Fatimah-Muis, Khris Heri-Nugroho, Ign Riwanto, Budi Widianarko.


Abstract
ABSTRACT
Purposes - Momordica charantia (MC) contains triterpenes, proteins, and steroids with anti-diabetic and antioxidative properties. Developing type 2 diabetes (T2DM) in prediabetes can be reduced by probiotics consumption. The pathogenesis and progression of diabetes are induced by oxidative stress and followed by elevated triglyceride and cholesterol levels. This study aimed to evaluate blood sugar levels and lipid profiles before and after treatment.

Experimental procedure - A total of 24 male Sprague-Dawley rats were induced by a single dose (60 mg/kg) of streptozotocin (STZ) and 120 mg/kg of nicotinamide. Following three days of induction, the rats were randomly divided into four groups and administered 10 ml/kg BW extract for 28 days. DM-MC was treated with MC extract. DM-FMC1 and DM-FMC2 were treated with fermented MC containing 3.7x107 CFU/ml and 3.7x1014 CFU/ml probiotics, respectively. DM-Ctrl was given distilled water. Blood glucose and lipid profile measurements were taken before and after treatment. The data was analyzed using a paired t-test, ANOVA and Tukey HSD for post hoc analysis. The level of significance was set at 0.05.

Findings – The groups treated with FMC2 significantly showed a decreased blood sugar level compared to MC and FMC1 (p<0.001), 89.4+3.94, 164.3+2.26, and 109.1+2.07, respectively. Lipid profiles showed the same pattern (p<0.001). Fermented MC substantially decreases blood glucose and lipid profile compared to the MC group (p<0.001).

Originality/value - In type 2 diabetes, reducing blood sugar levels and improving lipid profiles are significantly impacted by the presence and number of probiotics.

Key words: Fermented bitter melon, diabetes mellitus type 2, probiotics, hypolipidemic


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Laksmi Hartajanie
Articles by Siti Fatimah-Muis
Articles by Khris Heri-Nugroho
Articles by Ign Riwanto
Articles by Budi Widianarko
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

LH, SF, Heri-Nugroho K, Riwanto I, Widianarko B. A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles. J Res Complement Med. 2024; 1(1): 38-45. doi:10.5455/JRCM.20240215041123

Web Style

LH, SF, Heri-Nugroho K, Riwanto I, Widianarko B. A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles. https://www.scopub.com/jrcm/?mno=190853 [Access: April 18, 2024]. doi:10.5455/JRCM.20240215041123

AMA (American Medical Association) Style

LH, SF, Heri-Nugroho K, Riwanto I, Widianarko B. A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles. J Res Complement Med. 2024; 1(1): 38-45. doi:10.5455/JRCM.20240215041123


Vancouver/ICMJE Style

LH, SF, Heri-Nugroho K, Riwanto I, Widianarko B. A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles. J Res Complement Med. (2024), [cited April 18, 2024]; 1(1): 38-45. doi:10.5455/JRCM.20240215041123


Harvard Style

, L. H., , . S. F., Heri-Nugroho, . K., Riwanto, . I. & Widianarko, . B. (2024) A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles. J Res Complement Med, 1 (1), 38-45. doi:10.5455/JRCM.20240215041123


Turabian Style

, Laksmi Hartajanie, Siti Fatimah-Muis, Khris Heri-Nugroho, Ign Riwanto, and Budi Widianarko. 2024. A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles. Journal of Research in Complementary Medicine, 1 (1), 38-45. doi:10.5455/JRCM.20240215041123


Chicago Style

, Laksmi Hartajanie, Siti Fatimah-Muis, Khris Heri-Nugroho, Ign Riwanto, and Budi Widianarko. "A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles." Journal of Research in Complementary Medicine 1 (2024), 38-45. doi:10.5455/JRCM.20240215041123


MLA (The Modern Language Association) Style

, Laksmi Hartajanie, Siti Fatimah-Muis, Khris Heri-Nugroho, Ign Riwanto, and Budi Widianarko. "A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles." Journal of Research in Complementary Medicine 1.1 (2024), 38-45. Print. doi:10.5455/JRCM.20240215041123


APA (American Psychological Association) Style

, L. H., , . S. F., Heri-Nugroho, . K., Riwanto, . I. & Widianarko, . B. (2024) A comparative study: Probiotics number in fermented bitter melon (Momordica charantia) juice decreased blood sugar and lipid profiles. Journal of Research in Complementary Medicine, 1 (1), 38-45. doi:10.5455/JRCM.20240215041123


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesTerms of UseLicense InformationCopyright Information

About Journal of Research in Complementary Medicine

Journal of Research in Complementary Medicine is an international, peer-reviewed, open access journal, providing a platform for advances in basic, transl ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

Your comments are very important to us

We welcome your ideas, suggestions, comments, or questions. To reach Editorial Board please use one of the methods provided below.
 

Emails:

info@scopub.com
editorinchief@ejmanager.com

Office Address:
14 Rue de Grand-Bigard,
1082 Brussels
Belgium
 
We will respond within 48 to 72 hours.
 
Change of address or personal information? Please visit your account at www.ejmanager.com to update your information.